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Marcus, 41, Vancouver. Entrepreneur running Oura, WHOOP, and a CGM simultaneously. Spent ~$400/month on supplements. Persistent brain fog after noon, poor sleep quality despite "good" HRV scores, energy crashes mid-afternoon despite stable glucose.
COMT Val/Val — fast dopamine clearance. He was taking high-dose methylated B vitamins that further accelerated catecholamine metabolism, making the problem worse. Also CYP1A2 slow metaboliser: his 2pm coffee was still active at midnight, suppressing melatonin onset by 90+ minutes.
Removed methylated Bs, replaced with hydroxocobalamin and folinic acid. Cut caffeine to before 10am. Added phosphatidylserine to blunt his cortisol curve. Within 6 weeks: sleep quality up 34% by Oura scoring, afternoon crashes gone, cognitive sharpness sustained past 3pm.
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CYP1A2, CYP2D6, CYP2C19, ADH1B
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