Evidence-based articles on DNA optimisation, variant interpretation, and the science behind personalised protocols.
If you've tested positive for MTHFR C677T, you've probably already found the conflicting forum posts. Here's what the peer-reviewed literature actually says about the mechanism, the downstream consequences, and how your COMT genotype changes everything.
9 min read · Methylation
MethylationMTHFR A1298C operates through a different mechanism than C677T. It affects BH4 production and neurotransmitter synthesis rather than directly impairing folate conversion. Here is what the research actually says.
8 min read · Methylation
MethylationCT heterozygous means 35% reduced enzyme activity. TT homozygous means 70%. The clinical and intervention differences are larger than most popular content acknowledges. Here is what each actually means.
7 min read · Methylation
CognitionCOMT determines how fast you clear dopamine. Val/Val carriers handle stress well but have lower baseline cognition. Met/Met carriers think clearly at rest but break under pressure. Here is what the trade-offs actually mean.
8 min read · Cognition
TutorialStep-by-step guide to finding your MTHFR C677T (rs1801133) and A1298C (rs1801131) status in 23andMe or AncestryDNA raw data. No new test required.
5 min read · Tutorial
Protocol DesignMost supplement advice is built for the average human. Here's how CBS upregulation, VDR variants, and COMT genotype determine whether your current stack is helping, or quietly counterproductive.
7 min read · Protocol · Genomics
Women's HealthPCOS is not one condition. It's a cluster of metabolic and hormonal patterns with different genetic roots. CYP11A1, FSHR, INSR, and AMH variants determine whether your PCOS is androgen-driven, insulin-driven, or inflammatory.
10 min read · PCOS · Hormone
Women's HealthTestosterone isn't just a male hormone. In women, low free testosterone drives fatigue, low libido, brain fog, and loss of motivation — and standard panels almost never catch it. Here's how CYP19A1, SHBG, and AR variants determine your functional testosterone level.
8 min read · Hormone · Women's Health
Men's HealthTotal testosterone on a blood panel tells you very little. SHBG levels, aromatase activity, androgen receptor sensitivity, and cortisol metabolism — all genetically influenced — determine whether your testosterone is functionally adequate.
9 min read · Testosterone · Men's Health
Mental HealthAnxiety isn't a character flaw. For many people it has a measurable genetic basis — specific variants in COMT, MTHFR, and MAOA that directly influence dopamine clearance, serotonin metabolism, and stress hormone response.
11 min read · Anxiety · Mental Health
Women's HealthHashimoto's thyroiditis is the most common autoimmune condition worldwide, yet most people with it have never been told about the HLA variants, CTLA4 polymorphisms, and selenoprotein gene variants that determine their susceptibility.
10 min read · Autoimmune