Blog
Peer-reviewed research translated into plain language. No supplements to sell. No agenda. Just the evidence.
The mechanism, downstream consequences, and why dosing matters more than most guides admit.
A1298C affects BH4 production — a cofactor essential for serotonin, dopamine, and nitric oxide synthesis.
One copy vs two copies — the clinical differences and why compound heterozygosity is often overlooked.
Your COMT genotype determines how quickly you clear dopamine — and it changes everything about your supplement stack.
Step-by-step: locate rs1801133 and rs1801131 in your raw data file using rs IDs.
How CBS upregulation, VDR variants, and COMT genotype determine whether your current stack is helping or counterproductive.
The neurochemical basis of anxiety — and why the same protocol doesn't work for everyone.
Androgen-driven, insulin-driven, or inflammatory — your genetic phenotype determines which protocol works.
Standard panels almost never catch it. Here's how CYP19A1, SHBG, and AR variants determine your functional testosterone.
Total testosterone tells you very little. SHBG, aromatase, and AR sensitivity determine functional androgen status.
HLA variants, CTLA4, selenoprotein genes — the genetic architecture of the most common autoimmune condition.